Association of Pulse Dose Corticosteroids With Outcomes Among Patients With Acute Exacerbations of Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Background

Corticosteroids are a mainstay of treatment for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), but dosing practices vary. We leveraged between-hospital variation in propensity to administer pulse dose corticosteroids to determine the association between pulse dose corticosteroids and patient outcomes in AE-IPF.

Research question

Do outcomes differ for hospitalized patients who recieve pulse dose corticosteroids vs low dose corticosteroids for AE-IPF?

Study design and methods

We designed an instrumental variable study informed by a target trial framework using the Premier Healthcare Database (2016-2022). We identified adults ≥ 50 years of age with AE-IPF who received a dose of IV methylprednisolone within 2 days of admission. Our exposure of

SUBMITTER: Shankar DA 

PROVIDER: S-EPMC12774458 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature