Optimizing Diagnosis and Surgery for Pure Anterior Mediastinal Cysts: Insights from a Single-Centre Study.

ABSTRACT:

Objectives

Pure anterior mediastinal cysts (pAMC) are uncommon and typically benign lesions. In contrast to solid anterior mediastinal tumours, there are no standardized diagnostic or management guidelines, despite a small but clinically significant risk of malignancy. The goal of this study was to identify preoperative factors associated with malignancy in order to develop a clinical algorithm to guide the diagnosis and management of pAMC.

Methods

This retrospective single-centre study was conducted at Toulouse University Hospital and included patients diagnosed with pAMC between January 2012 and June 2025. Logistic regression was used to identify preoperative predictors of thymoma or germ cell tumours.

Results

A total of 70 patients were diagnosed with pAMC, 26 of w

SUBMITTER: Rieg A 

PROVIDER: S-EPMC12774464 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature