A Biologically Inert Tamoxifen-derived Long-lasting Hydrogel-mediated Immunochemotherapy Can Mitigate Tumour Progression and Activate T Cell Immunity.

ABSTRACT: The immunosuppressive tumour microenvironment (TME) is often regarded as the Achilles heel of cancer therapy, as it can limit immune cell infiltration and therapeutic efficacy. To address this, we engineered a long-lasting tetrapeptide-conjugated lithocholic acid-tamoxifen-derived injectable hydrogel (LTG4-Gel) that, upon implantation, does not exert any systemic toxicity in mice, rats and rabbits. LTG4-Gel retained its injectability and rheological flow properties even after the entrapment of multiple drugs, as confirmed by rheology, UV absorption, circular dichroism and atomic force microscopy. Doxorubicin (DOX) entrapped hydrogel (DOX-Gel) significantly induced the anti-tumour responses with enhanced survival in different syngeneic murine tumour models. We further showed that the engine

SUBMITTER: Jha SK 

PROVIDER: S-EPMC12774480 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature