GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells.

ABSTRACT: Tissue-resident memory CD8 T (T_RM) cells provide critical antiviral and antitumor immunity, but the molecular pathways guiding their development are not fully defined. Here, we identify the G protein-coupled receptor GPR25, induced by TGF-β signaling, as a regulator of T_RM cell formation. Using adoptive transfer, we found that Gpr25-deficient T cells infiltrated tissues normally after viral infection but failed to efficiently develop into T_RM cells. In a tumor challenge model, Gpr25 deficiency impaired T_RM cell expansion and tumor control. Single-cell transcriptomics revealed defective acquisition of stem-like T_RM cell features, including expression of T cell factor 1 (TCF1). After antigen rechallenge, Gpr25-defici

SUBMITTER: Feng H 

PROVIDER: S-EPMC12774532 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature