Clinical Features Associated With Malignant Transformation of Low-Grade Dysplasia.

ABSTRACT:

Background

Inferring risk for malignant transformation (MT) in patients with lesions diagnosed as mild or moderate oral epithelial dysplasia (low-grade OED) remains challenging. We developed two models assessing the risk of progression to high-grade OED (severe dysplasia or carcinoma in situ) or OSCC in patients with low-grade OED lesions.

Methods

We included demographic, risk habit and clinical data from participants with low-grade OED lesions enrolled in the BC Oral Cancer Prevention Program's Oral Cancer Prediction Longitudinal study. Cox proportional hazard models were fit to estimate the effects of anatomic site and toluidine blue findings and adjusted for confounders, as both are associated with MT in the literature but without a North American-specific cohort analysis

SUBMITTER: Laronde DM 

PROVIDER: S-EPMC12774577 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature