DNATCO v5.0: integrated web platform for 3D nucleic acid structure analysis.

ABSTRACT: As the number and complexity of RNA and DNA structures continue to expand, there is a growing need for robust yet accessible tools that support their accurate interpretation, validation, and refinement. We present DNATCO v5.0 (dnatco.datmos.org), an interactive web application for comprehensive structural analysis of nucleic acids. DNATCO integrates the NtC dinucleotide conformational classes and the CANA structural alphabet to provide an intuitive, geometrically complete description of local backbone and base orientations, complemented by interactive visualization of base pairing. The platform performs quantitative validation of conformational similarity and covalent bond lengths and angles, using newly established nucleic-acid valence-geometry standards. Quantitative validation encompass

SUBMITTER: Cerny J 

PROVIDER: S-EPMC12774647 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature