Biopsy Morphometrics as Predictors of Treatment Response in Primary Nephrotic Syndrome.

ABSTRACT:

Rationale & objective

Clinical outcome of primary nephrotic syndrome (PNS) is highly variable, and predicting an individual patient's treatment response remains difficult. PNS is characterized by means of podocyte injury and loss. We hypothesized that histologic parameters related to podocyte depletion predict treatment response.

Study design

Retrospective cohort study.

Setting & participants

We analyzed biopsy tissue of 106 patients with PNS (minimal change disease, N = 26; focal segmental glomerulosclerosis, N = 21; and membranous nephropathy [MN], N = 59) and 9 controls. Minimal change disease and focal segmental glomerulosclerosis were considered manifestations of the same entity, defined as idiopathic nephrotic syndrome (iNS), and analyzed as one group. Patients'

SUBMITTER: van den Berge BT 

PROVIDER: S-EPMC12774748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature