Chimeric reference panels for genomic imputation.

ABSTRACT: Despite transformative advances in genomic technologies, missing data remain a fundamental constraint that limits the full potential of genomic research across biological systems. Genotype imputation offers a remedy by inferring unobserved genotypes from observed data. However, conventional imputation methods typically rely on external reference panels constructed from complete genome sequences of hundreds of individuals, a costly approach largely inaccessible for nonmodel organisms. Moreover, these methods generally overlook novel genomic positions not captured in existing panels. To overcome these limitations, we developed Retriever, a method for constructing a chimeric reference panel that enables genotype imputation without the need for an external reference panel. Retriever constructs

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12774824 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature