Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD.

ABSTRACT: Understanding how genetic variants drive phenotypic differences is a major challenge in molecular biology. Single nucleotide polymorphisms form the vast majority of genetic variation and play critical roles in complex, polygenic phenotypes, yet their functional impact is poorly understood from traditional gene-level analyses. In-depth knowledge about the impact of single nucleotide polymorphisms has broad applications in health and disease, population genomic, and evolution studies. The wealth of genomic data and available functional genetic tools make Drosophila melanogaster an ideal model species for studies at single nucleotide resolution. However, to leverage these resources for genotype-phenotype research and potentially combine it with the power of functional genetics, it is essentia

SUBMITTER: Beets J 

PROVIDER: S-EPMC12774831 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature