Postoperative radiotherapy for ductal carcinoma in situ: survival prediction and clinical decision support using a nomogram-based approach.

ABSTRACT: Whether postoperative radiotherapy (RT) is required for ductal carcinoma in situ (DCIS) after breast-conserving surgery (BCS) remains controversial. In this study, we aimed to analyze the association between postoperative RT and survival outcomes in DCIS patients and develop nomograms to predict these outcomes. Using data on 50,580 DCIS patients obtained from the surveillance, epidemiology, and end results (SEER) database, the Chi-squared tests revealed that DCIS patients with younger age, partial mastectomy, larger tumor size, negative estrogen receptor (ER) status, and higher nuclear grade, were more likely to receive postoperative RT. Additionally, Postoperative RT could improve the overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) across most patie

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12774880 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature