Cortical dynamics and network alterations in Parkinson's disease with mild cognitive impairment: TMS-EEG study of the posterior parietal cortex.

ABSTRACT: Individuals with mild cognitive impairment (MCI) in Parkinson's disease (PD) are significantly susceptible to developing dementia. Investigating cortical dynamics within the posterior parietal cortex (PPC) may elucidate the mechanisms underlying cognitive decline in PD. Using combined transcranial magnetic stimulation-electroencephalography, this study assessed cortical excitability, time-frequency oscillations, and functional network dynamics after stimulation of the right PPC in 45 PD patients (23 with MCI, 22 with normal cognition). Results showed that PD-MCI patients exhibited increased TMS-evoked potentials across the frontal-parietal-occipital cortex compared to cognitively normal PD patients, accompanied by enhanced theta and alpha oscillation synchronization. Functional connectivit

SUBMITTER: Pei G 

PROVIDER: S-EPMC12774898 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature