The structure-dependent effects of newly synthesised cationic gemini surfactants against yeast cells.

ABSTRACT: The mechanism of action of cationic gemini surfactants, namely dimethyl{{3-[N-(3-{N-[3-(dimethylammonium)propyl]alkylamido}propyl}dodecylamido}propyl}}ammonium dibromides (2xCnBrG3, n = 12, 14), dimethyl carbonates (2xCnMeCO3G3, n = 12), and dimethyl{{3-[N-(3-{N-[3-(dimethylamine)propyl]alkylamido}propyl}dodecylamido}propyl}}amine dihydrochlorides (2xCnHClG3, n = 12, 14), was investigated in Saccharomyces cerevisiae cells. Studies indicated the influence of the chemical structure of these compounds on their activity. The tested cationic gemini surfactants increased K⁺ ion leakage from yeast cells. Moreover, these compounds elevated the intracellular content of both saturated and unsaturated fatty acids, as well as sterols (ergosterol, zymosterol, lanosterol). Especially, compounds 2xC14BrG

SUBMITTER: Mazurkiewicz E 

PROVIDER: S-EPMC12774919 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature