Osteosarcopenia, bone-muscle interactions, and frailty risk: A prospective cohort study of community-dwelling older adults.

ABSTRACT:

Background

Osteosarcopenia, defined as the co-existence of osteopenia/osteoporosis and sarcopenia, may influence frailty risk in older adults. However, the longitudinal association between osteosarcopenia or its components and frailty remain unclear. This study aimed to address this.

Methods

Data from a prospective cohort study of community-dwelling adults in Australia. Frailty was defined by the presence of ≥ 3 components based on Fried criteria: exhaustion, slow gait speed, low grip strength, unintentional weight loss, and low physical activity. Osteosarcopenia was defined by osteopenia/osteoporosis (WHO criteria) and sarcopenia (European Working Group on Sarcopenia in Older People [EWGSOP2] and Sarcopenia Definition and Outcome consortium [SDOC]). Multivariable logistic r

SUBMITTER: Fatima M 

PROVIDER: S-EPMC12774941 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature