Mechanochemical ligand-controlled regiodivergent hydroarylation of alkenes via iron-catalyzed C-H activation.

ABSTRACT: The iron-catalyzed hydroarylation of alkenes with indoles is a sustainable, effective synthetic transformation towards the construction of functionalized indoles - crucial motifs for various bioactive molecules and drug candidates. However, such transformations have proven challenging for unactivated alkenes, and the requirement for (super)stoichiometric amounts of reactive Grignard reagents has limited broader applications. Herein, we address these major challenges by integrating iron/N-heterocyclic carbene-catalyzed C-H activation with mechanochemistry techniques. This approach enables mechanochemical iron-catalyzed anti-Markovnikov hydroarylations of unactivated alkenes using a bis(N-heterocyclic carbene) ligand, as well as regiodivergent hydroarylation of aryl alkenes by varying the N-

SUBMITTER: Zhang ZJ 

PROVIDER: S-EPMC12774961 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature