The Inflammation-Energy Metabolism Axis: A Central Driver of Sarcopenia-Osteoporosis: A Narrative Review.

ABSTRACT: Sarcopenia-osteoporosis, the concomitant loss of muscle and bone mass, is a geriatric comorbidity that significantly increases the risk of falls, fractures, and mortality. Despite the acknowledgment of muscle-bone crosstalk, the underlying mechanism driving their simultaneous decline remains poorly understood, resulting in a lack of effective integrated therapies. This review aims to elucidate the "inflammation-energy metabolism axis" as the central driver of this condition. This review contends that sarcopenia-osteoporosis is not a coincidental comorbidity but a single pathological syndrome driven by the failure of the inflammation-energy metabolism axis. Its pathophysiology is a self-sustaining vicious cycle where chronic low-grade inflammation (inflammaging) and dysregulated energy meta

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12774982 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature