Rapid enantioselective fluorescence recognition and chiral separation of free amino acids.

ABSTRACT: Enantioselective recognition and chiral separation of amino acids hold significant importance in chemistry, materials science, and life science. Here, we report a water-soluble chiral fluorescent probe that enables visual chiral recognition and separation by incorporating a morpholinium quaternary cation into the 1,1'-bi-2-naphthol frameworks. Upon binding with free amino acid enantiomers, the probe achieves rapid chiral discrimination within 100 s, accompanied by distinct changes in luminescence color or intensity. The underlying mechanism of this chiral recognition involves imine formation and electrostatic interactions, accompanied by aggregation-induced emission. These processes collectively promote selective aggregation and precipitation between the probe and specific enantiomers of a

SUBMITTER: Li Y 

PROVIDER: S-EPMC12774986 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature