Mapping intralobar fiber connections in the human occipital lobe by tracer electrophoresis.

ABSTRACT: The cellular connectivity of the human visual cortex remains largely uncharted, with most insights derived from animal models. A custom-designed tracer electrophoresis setup for polar lipophilic tracers enabled the reconstruction of fiber tracts in fixed postmortem human brains, visualizing their trajectories across previously unmapped distances, from cellular origins to axonal terminations. Applied to the occipital lobe, four pathways of the calcarine cortex were demonstrated: the stratum calcarinum, stratum proprium cunei, fasciculus transversus cunei, and the fasciculus transversus gyri lingualis. Specifically, axonal projections from granular and supragranular layers of the calcarine cortex were traced to the granular and supragranular layers of the cuneus, inferior, middle, and superi

SUBMITTER: Freudenmacher L 

PROVIDER: S-EPMC12774988 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature