Prognostic implications of CD15 antigen expression in patients with acute myeloid leukemia.

ABSTRACT: The prognostic significance of CD15 antigen in acute myeloid leukemia has been evaluated with conflicting results in various studies. However, existing results are limited and further investigation into additional prognostic parameters is necessary. This study aimed to evaluate the impact of CD15 antigen on survival prognosis in patients with de novo AML (dn-AML). We analyzed CD15 antigen expression on diagnostic samples from 676 patients with dn-AML by flow cytometry. Utilizing a 20% positivity threshold, the cohort was stratified into CD15 positivity (56.07%) and CD15 negativity (43.93%) groups. The CD15 negativity group demonstrated a lower complete remission rate (P = 0.006), a higher relapse rate (P = 0.002) and increased mortality (P<0.001) compared to the CD15 positivity group. Acco

SUBMITTER: Li Z 

PROVIDER: S-EPMC12775031 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature