Third-generation Cephalosporin resistance in Sub-Saharan Africa: a systematic review and meta-analysis.

ABSTRACT:

Background

Antimicrobial resistance is a critical global health threat, with Sub-Saharan Africa disproportionately affected. Third-generation cephalosporins are widely used for severe infections due to their safety, broad spectrum, and effectiveness. However, resistance to third-generation cephalosporins undermines treatment and exacerbates poor outcomes in regions with limited alternative therapies. This systematic review and meta-analysis evaluated the prevalence, temporal trends, and geographical variations of resistant pathogens in Sub-Saharan Africa.

Methods

We searched three databases from the inception until 16^th August 2024 for observational studies reporting third-generation cephalosporin resistant infections in Sub-Saharan Africa. Eligible studies report

SUBMITTER: Guido G 

PROVIDER: S-EPMC12775075 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature