Atherogenic index of plasma and cognitive impairment risk among hypertensive adults: evidence from a nationwide cohort study.

ABSTRACT:

Background

Cognitive impairment is a major complication in individuals with hypertension. Emerging evidence suggests that metabolic abnormalities may contribute to its pathogenesis. This study examined the association between the atherogenic index of plasma (AIP) and risk of cognitive impairment in middle-aged and older adults with hypertension.

Methods

Data were from the 2011 baseline and 2018 follow-up waves of the China Health and Retirement Longitudinal Study (CHARLS). Multivariable logistic regression was used to assess the association between baseline AIP and subsequent cognitive impairment. Dose-response patterns were explored using restricted cubic spline (RCS) models, and subgroup analyses evaluated effect modification. Predictive performance of AIP versus tradition

SUBMITTER: Bai W 

PROVIDER: S-EPMC12775095 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature