Association between low handgrip strength and the increased risk of age-related macular degeneration: results from UK biobank cohort study.

ABSTRACT:

Objectives

To determine whether handgrip strength is associated with the incidence of age-related macular degeneration.

Methods

A prospective cohort study of over 500 thousand UK Biobank participants aged 40-69 years. Individuals ≥ 50 years and without age-related macular degeneration at baseline were included. Exposure was the handgrip strength measured by dynamometer. Primary outcome was the incidence of age-related macular degeneration during 13 years of follow-up. Cox proportional-hazard models were fitted to estimate the risk effect for handgrip strength on age-related macular degeneration, and stratified for sociodemographic and lifestyle factors. Mediation models were regressed to explore underlying mechanisms driven by inflammatory and erythrocyte-related biomarkers.

SUBMITTER: Wang S 

PROVIDER: S-EPMC12775100 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature