Circulating exosomal miR-20b-5p and miR-1273g-3p were potential biomarkers for diagnosis and prognosis of acute coronary syndrome.

ABSTRACT:

Background

Acute coronary syndrome (ACS) remains one of the leading causes of mortality worldwide. This study investigates the diagnostic and prognostic value of circulating exosomal miR-20b-5p and miR-1273g-3p in ACS.

Methods

This retrospective study randomly included 138 patients diagnosed with ACS according to the 2020 European Society of Cardiology (ESC) Guidelines for managing ACSs and 129 controls with normal coronary arteries (NCA) between October 2020 and November 2023 in Meizhou People's Hospital. Plasma-derived exosomes were isolated from patients with ACS and NCA controls. The expression of miR-20b-5p and miR-1273g-3p was measured using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Major adverse cardiovascular events (MACEs) within 1 year

SUBMITTER: Weng R 

PROVIDER: S-EPMC12775160 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature