Effects of beta-cyclodextrin-Combretastatin A-4 nanoparticles containing selenium on apoptosis and metastasis of U-87MG glioblastoma cancer cells.

ABSTRACT:

Background

Glioblastoma (GBM), the most aggressive primary brain tumor, faces significant treatment challenges due to drug resistance, blood-brain barrier limitations, and severe side effects of conventional therapies. This study aimed to develop and evaluate a nanotechnology-based therapeutic approach using selenium-loaded β-cyclodextrin-combretastatin A-4 nanoparticles (Se(B-CD-CA-4-NPs)) to overcome these limitations and enhance treatment efficacy.

Methods

The Se(B-CD-CA-4-NPs) complex was synthesized and characterized for morphology, size, stability, and selenium loading capacity. In vitro studies included MTT assay, cell apoptosis, scratch assay, gelatin zymography, and qPCR were used to assess the effect of the newly synthesized complex on U-87MG glioblastoma cell viab

SUBMITTER: Hosseini SM 

PROVIDER: S-EPMC12775192 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature