Exosomal TACSTD2 promotes invasion, metastasis and glycolysis in ovarian cancer.

ABSTRACT:

Background

Tumour-derived exosomes are involved in various cancer processes, including invasion, metastasis, and tumour microenvironment (TME) remodelling. However, the function and mechanism of exosomes in ovarian cancer (OC) are still under investigation. The present study investigated the effects of tumour-derived exosomes on the carcinogenesis and progression of OC.

Methods

OC gene expression profiles were obtained from The Cancer Genome Atlas (TCGA) database and two independent Gene Expression Omnibus (GEO) datasets (GSE7463 and GSE12470). The exosome related genes were obtained by intersecting with OC related exosomes in the ExoCarta database, subsequently, the exosome genes of interst were identified through performing survival analysis in the GEPIA database.The expre

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC12775207 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature