Nox3 expression and function in retinal ganglion cells and Amacrine cells.

ABSTRACT: NADPH oxidase 3 (Nox3), expressed in the endolymphatic duct and sac within the vestibule of the inner ear, is essential for otoconia formation. Mice with functionally deficient Nox3 exhibit a "head-tilt" phenotype. Recently, we reported that Nox3 expression in the cochlea is induced by aging, cisplatin treatment, and intense noise exposure, contributing to the primary source of reactive oxygen species (ROS) and causing acquired sensorineural hearing loss. However, its expression and function outside the inner ear remain poorly characterized. To explore novel Nox3 functions, we used Nox3-Cre;tdTomato mice, in which Cre recombinase (Cre) is knocked into the ATG site of Nox3, enabling visualization of Nox3 expression via tdTomato fluorescence. We identified Nox3 expression in retinal ganglion

SUBMITTER: Ueyama T 

PROVIDER: S-EPMC12775227 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature