Renal limited sarcoidosis presenting with non-caseating granulomatous interstitial nephritis in the absence of extrarenal manifestations: a case report and literature review.

ABSTRACT: Renal limited sarcoidosis is an exceptionally rare condition characterized by non-caseating granulomas confined solely to the kidneys, without involvement of other organs. Its diagnosis is challenging because of the absence of systemic manifestations. We present a case of a 74-year-old woman with a history of type 2 diabetes mellitus, papillary thyroid carcinoma, and osteoporosis, who showed progressive renal dysfunction. Laboratory findings revealed elevated serum creatinine and urinary β₂-microglobulin, indicating tubular injury. Kidney biopsy demonstrated granulomatous interstitial nephritis with non-caseating epithelioid cell granulomas. Other potential causes, including infections, drug-induced nephritis, and autoimmune diseases were excluded. Chest computed tomography and gallium-67

SUBMITTER: Yanagisawa K 

PROVIDER: S-EPMC12775233 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature