Bioactive molecule delivery platforms in regenerative endodontic therapy: A systematic review and meta-analysis.

ABSTRACT: This systematic review examines emerging delivery systems for bioactive molecules within regenerative endodontic therapy (RET) where hydrogels, nanogels, and polymeric nanoparticles along with advanced nanocarriers such as liposomes aquasomes, vesosomes, and mesoporous silica nanoparticles form the primary focus. The extensive literature search in PubMed, Scopus, and Web of Science databases (until August 2025) yielded a total of 47 eligible articles, including in vitro, ex vivo, animal, and a few clinical studies. Hydrogels emerged as a significant category, showcasing enhanced regenerative effects when used for the sustained release of various growth factors such as transforming growth factor-beta (TGF-β₁), bone morphogenetic protein-2 (BMP-2), and vascular endot

SUBMITTER: Kaur K 

PROVIDER: S-EPMC12775354 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature