Correlation between spectroscopic and stoichiometric protein to lipid ratios in erythrocyte-derived extracellular vesicles and nanoerythrosomes.

ABSTRACT: The erythrocyte-derived extracellular vesicles and nanoerythrosomes show high similarities due to their same origins supporting their prosperous applicability for new generations of nanocarrier systems. By the addition of a representant erythrocyte-membrane lipid which is the saturated dipalmitoyl-phosphocholine (DPPC), different morphological and structural changes occurred in function of the increasing DPPC ratio. The integration of guest DPPC molecules, expressed in weight ratio extending to an order of magnitude, yields the formation of standalone nanoerythrosomes (NERYs), while the integration of DPPC molecules is significantly reduced into red blood cell derived extracellular vesicles (RBCEVs) causing aggregations of these EVs. Despite the induced severe and different changes in morp

SUBMITTER: Bota A 

PROVIDER: S-EPMC12775370 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature