Lipid pathways connecting maternal BMI with infant obesity risk.

ABSTRACT: Maternal obesity is a key determinant of infant health, increasing early-life obesity risk. Lipids are mechanistically linked to obesity and may mediate intergenerational transfer, by influencing foetal or infant lipids. Using the Barwon Infant Study, we investigated associations between maternal pre-pregnancy body mass index (pp-BMI), lipidomic profiles of mothers, human milk, and infants, and early life growth. Ether lipids were of particular interest due to their abundance in human milk, association with breastfeeding, and roles in metabolism and inflammation. Linear regression analyses assessed relationships between maternal pp-BMI and lipid profiles across biospecimens, and infant BMI. A composite plasmalogen score, reflecting ether lipid metabolism, was developed due to its strong as

SUBMITTER: George AD 

PROVIDER: S-EPMC12775464 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature