Nanoarchaeosomes for synergistic photochemotherapy in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) poses significant therapeutic challenges due to the lack of targetable receptors and the systemic toxicity associated with conventional treatments such as surgery, radiotherapy, and chemotherapy. While phototherapy has emerged as a potential alternative, its clinical translation is hindered by the colloidal instability of photothermal agents and the need for combinatorial strategies. Here, we report the development of a near-infrared (NIR)-responsive theranostic nanoplatform based on archaeal lipid-derived nanoarchaeosomes (NA) co-encapsulating cisplatin (Cis) and PEGylated gold nanorods (AuNRs), forming a multifunctional NA-Cis-AuNRs nanoformulation. Archaeal lipids confer robust colloidal stability to this complex, enabling high drug-loading efficienc

SUBMITTER: Basha SS 

PROVIDER: S-EPMC12775512 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature