Differential Impact of BMI-Associated Genetic Variants on Breast Cancer Risk: Insights From Mediation Analysis.

ABSTRACT: Obesity is a known risk factor for breast cancer, particularly in postmenopausal women. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with body mass index (BMI). We conducted a case-control study with 1273 breast cancer cases and 4816 controls to examine whether five BMI-associated SNPs (rs939584 [TMEM18], rs4409766 [BORCS7-ASMT], rs6265 [BDNF], rs1927790 [HS6ST3], rs1421085 [FTO]) influence breast cancer risk through BMI-dependent or -independent pathways using mediation analysis. For postmenopausal breast cancer, rs6265 (C > T) exhibited a carcinogenic direct effect (odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.04-1.34) along with a protective indirect effect through changes in BMI (OR = 0.98, 95% CI 0.96-0.99), while rs14210

SUBMITTER: Ando Y 

PROVIDER: S-EPMC12775586 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature