Quantitative dynamic granzyme B PET imaging to characterize novel combination immunotherapy response in preclinical glioblastoma models.

ABSTRACT: Rationale: Immune-targeted positron emission tomography (PET) allows for the non-invasive monitoring of immune populations with potential to provide early markers of response to novel immunotherapies in glioblastoma (GBM). Dynamic PET acquisitions can inform on tracer kinetics via dynamic modeling to enhance the GBM tumor microenvironment characterization, while its impact has yet to be understood. The objective of this study is to evaluate the quantitative description of dynamic granzyme B (GZP)-PET imaging and its ability to inform on combination immunotherapy response in orthotopic syngeneic GBM models. Methods: Orthotopic GBM murine models (GSC005-luc) were imaged with dynamic [⁶⁴Cu]-NOTA-GZP PET (0-80 min) and T₂ -weighted MRI one week post-t

SUBMITTER: Gallegos CA 

PROVIDER: S-EPMC12775653 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature