Targeting ferroptosis to overcome drug resistance in lung cancer.

ABSTRACT: Lung cancer represents one of the most prevalent malignant tumors and the leading cause of mortality from neoplastic diseases worldwide. Despite significant advancements of lung cancer treatment in recent years, thanks to advancements in technologies such as chemotherapy, targeted therapy, immunotherapy, and so on, the development of drug resistance in lung cancer remains a major challenge. Ferroptosis, dependent on iron and accompanied by lipid peroxidation, is a unique form of cell death. Strategies targeting ferroptosis, either by blocking antioxidant defense pathways or activating oxidative pathways, are usually aimed at killing cancer cells or boosting cancer therapy effectiveness. The regulation of ferroptosis entails synergistic interactions among multiple pathways. Core pathways, i

SUBMITTER: Sheng P 

PROVIDER: S-EPMC12775696 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature