O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer.

ABSTRACT:

Background

Limited evidence exists on the role of protein glycosylation, particularly O-GlcNAcylation (O-GlcNAc), in predicting radiotherapy (RT) response in non-small cell lung cancer (NSCLC). This study aimed to investigate O-GlcNAc expression, glucose metabolism indicators, and their associations with RT response and prognosis in NSCLC.

Methods

We conducted a retrospective cohort study of 216 NSCLC patients who underwent RT and positron emission tomography-computed tomography (PET-CT) imaging. O-GlcNAc expression in pretreatment primary tumor specimens was evaluated by immunohistochemistry (IHC), and patients were categorized into high- and low-expression groups. All patients were matched for age, sex, diagnosis, and pathological stage. Clinical features were reviewed, an

SUBMITTER: Wang X 

PROVIDER: S-EPMC12775701 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature