A lactylation-driven prognostic model for lung adenocarcinoma: cellular lactylation heterogeneity and immune insights.

ABSTRACT:

Background

Lactylation, a recently identified post-translational modification, plays a critical role in tumor progression and immune regulation. However, its cellular heterogeneity and functional impact in lung adenocarcinoma (LUAD) remain poorly understood. This study was designed as exploratory biological research to characterize lactylation-associated patterns at the single-cell level and to propose a potential lactylation-related prognostic model.

Methods

Single-cell transcriptomic data from LUAD and normal lung tissues were analyzed to quantify lactylation activity using AUCell based on 332 lactylation-related genes. Cell-cell communication was inferred using CellChat to identify ligand-receptor interactions among subpopulations. Candidate genes were selected by integra

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12775714 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature