Dosage adjustments in renal impairment among medical ward patients: ChatGPT® and DeepSeek® models' effectiveness in assessing those adjustments.

ABSTRACT:

Background

Due to altered drug clearance, renal impairment necessitates drug dose adjustments to prevent toxicity or therapeutic failure, yet inappropriate dosing persists. The utility of AI tools (e.g., ChatGPT®, DeepSeek®) in supporting renal dose adjustments remains understudied.

Objective

Evaluate renal dose adjustment practices in hospitalized patients and compare AI models (ChatGPT®, DeepSeek®) against UpToDate® guidelines.

Method

A prospective observational study (January-April 2024) included hospitalized patients with creatinine clearance <60 mL/min in a general medicine ward. Medication regimens were assessed against UpToDate® guidelines. Five AI models (ChatGPT® 3.5, ChatGPT® 4.0, ChatGPT® 5.0, DeepSeek®, DeepThink®) were tested using 348 tailored prompts; s

SUBMITTER: Thapa RB 

PROVIDER: S-EPMC12775794 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature