Temporal multi-tissue profiling reveals metabolites linked to immune response and malaria parasitemia control.

ABSTRACT: Malaria causes significant metabolic changes and cytokine production in the patient. The effects of species- and strain-specific immunity, as well as metabolic disorders, on malaria severity remain poorly understood. Here, we infected C57BL/6n mice with four P. yoelii strains and P. berghei ANKA (PbA), collected blood, spleen, and liver tissue samples on days 4 and 6 post-infection, and measured metabolite levels using LC-MS/MS. Tissue- and strain-specific metabolic alterations in glycolysis intermediates, amino acids, and nucleotides were identified and correlated with cytokine levels and parasitemia. Glycolysis intermediates, including bisphosphoglycerate, phosphoenolpyruvate, and dihydroxyacetone phosphate, were negatively correlated with parasitemia, suggesting consumptio

SUBMITTER: Teklemichael AA 

PROVIDER: S-EPMC12775866 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature