Causal Relationships Between Major Depressive Disorder and Coronary Artery Disease Across Diverse Populations: A Bidirectional Mendelian Randomisation Study.

ABSTRACT:

Background and objectives

Coronary artery disease remains the leading cause of cardiovascular mortality worldwide, with a disproportionate burden in low- and middle-income countries. Although observational studies have established a bidirectional relationship between depression and coronary artery disease, the underlying genetic basis of this association remains unclear, particularly in underrepresented diverse-ancestry populations. Establishing whether this relationship is causal and whether it differs by ancestry is critical for informing targeted and equitable prevention strategies.

Methodology

This study employed a bidirectional two-sample Mendelian randomisation framework to investigate the causal relationship between major depressive disorder and coronary artery diseas

SUBMITTER: Silva S 

PROVIDER: S-EPMC12775895 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature