Metastasis of lung adenocarcinoma to follicular thyroid carcinoma combined with papillary thyroid carcinoma in the contralateral lobe: A case report.

ABSTRACT: Cancer-to-cancer metastasis is uncommon. The present study describes a case in which lung adenocarcinoma (LC) metastasized to follicular thyroid carcinoma (FTC). A 46-year-old Chinese woman exhibited a solid carcinoma (~60×40 mm) that nearly replaced the entire thyroid tissue of the left lobe, along with papillary thyroid carcinoma (PTC) in the right lobe. The initial clinical manifestation appeared as a thyroid neoplasm. Histological examination revealed two admixed components within the neoplasm of the left lobe: FTC and an adenocarcinoma component. The mutational profile of LC was analyzed using next-generation sequencing, revealing an epidermal growth factor receptor gene mutation at exon 21 (L858R) in the LC tissue. Differentiating between two tumor populations can be challenging when

SUBMITTER: Wang C 

PROVIDER: S-EPMC12775899 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature