Isotoxic stereotactic reirradiation for recurrent pelvic cancers.

ABSTRACT:

Background and purpose

Reirradiation is clinically challenging, requiring a balance between delivery of dose to tumour while respecting cumulative organ at risk (OAR) dose constraints. Standard prescriptions are often conservative, ignoring patient variability in achievable OAR doses. Isotoxic radiotherapy individualises treatment by delivering the highest equieffective dose in 2 Gy per fraction (EQD2Gy) while meeting OAR constraints. This technical feasibility study assessed isotoxic pelvic reirradiation using cumulative OAR constraints, the original dose distribution as background, and voxel-by-voxel EQD2Gy optimisation.

Materials and methods

Data from 30 patients previously treated with pelvic stereotactic body radiotherapy (SBRT) at three UK centres were included. OARs w

SUBMITTER: Pagett CJH 

PROVIDER: S-EPMC12775924 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature