Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study.

ABSTRACT:

Background

Closure of a patent foramen ovale (PFO) is frequently recommended in patients with cryptogenic stroke. Long-term outcomes in real-world settings remain unknown.

Objectives

This study analyzed standardized mortality ratio (SMR), subsequent stroke, and associated risk factors after PFO closure.

Methods

National registers on congenital heart disease and stroke were cross-linked to identify individuals who underwent PFO closure between 2001 and 2018. The ratio of observed to expected deaths was calculated (SMR). Data were analyzed using survival analysis and Cox regression.

Results

A total of 827 patients (60.5% males, median age 47.9 years, IQR: 40.0-55.6 at the time of PFO closure) were included and observed for a median duration of 8.0 years (IQR: 4.8

SUBMITTER: Angerbjorn M 

PROVIDER: S-EPMC12775957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature