Differentiating effects of levodopa and subthalamic nucleus deep brain stimulation on motor features in Parkinson disease.

ABSTRACT:

Introduction

While deep brain stimulation of the subthalamic nucleus (STN DBS) is traditionally used to treat motor fluctuations in Parkinson disease (PD), recent progress in levodopa delivery systems may offer non-invasive alternatives to surgical options. To gain insight into symptoms more likely to be treated effectively by STN DBS or levodopa, we systematically compared the differential effects of levodopa and STN-DBS on specific parkinsonian motor components.

Methods

We retrospectively analyzed 395 PD patients who received bilateral STN-DBS at Washington University (1999-2020). UPDRS-III was obtained in three conditions: preoperative OFF-medication, preoperative ON-medication, and postoperative ON-DBS/OFF-medication. Exploratory factor analysis identified a consensus st

SUBMITTER: Lee TA 

PROVIDER: S-EPMC12775982 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature