Synergistic effects of genetic susceptibility and air pollution on cardiovascular disease.

ABSTRACT:

Background

Although both genetic susceptibility and air pollution are established risk factors for cardiovascular disease (CVD), evidence for their interaction, particularly on the additive scale, remains limited and inconclusive. We aimed to investigate the individual and joint effects of long-term exposure to air pollutants and polygenic risk on incident CVD.

Methods

In a prospective cohort of 460,572 participants from the UK Biobank, we estimated hazard ratios (HRs) for CVD associated with particulate matter (PM_2.5 and PM₁₀), nitrogen dioxide (NO₂), and nitrogen oxides (NO _X ) using Cox models. A polygenic risk score (PRS) for CVD was constructed, and additive and multiplicative interactions between PRS and air pollution

SUBMITTER: Cheng YJ 

PROVIDER: S-EPMC12775991 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature