The impact of ceftazidime-avibactam on 30-day mortality in the treatment of OXA-48 producing <i>Enterobacterales</i> infections: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To assess the impact of ceftazidime-avibactam on 30-day all-cause mortality in patients with OXA-48 producing Enterobacterales infections, in comparison to alternative best available therapy (BAT).

Methods

Systematic review and meta-analysis of observational studies comparing 30-day mortality outcomes in patients infected with OXA-48 producing Enterobacterales, treated with ceftazidime-avibactam versus BAT. Clinical success (improvement in symptoms/signs of infection) at the end of therapy was assessed as a secondary outcome. We searched six electronic databases (PubMed, EMBASE, CINAHL, Scopus, CENTRAL, Web of Science). Two independent authors carried out the title and abstract review, full text review and data extraction.

Results

We included

SUBMITTER: Foo AL 

PROVIDER: S-EPMC12776013 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature