Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity in <i>Drosophila</i>.

ABSTRACT: Circadian clocks orchestrate daily physiology and behavioral rhythms, yet the extent to which cells lacking canonical clock components exhibit robust temporal regulation remains unclear. Here we addressed this question using a two-step strategy. First, we systematically mapped core clock gene expression at single-cell resolution across the Drosophila brain and body. Second, leveraging these data and performing targeted experiments, we uncovered cells that lack most or all canonical clock components yet display strong mRNA rhythms. We found that lamina wide-field neurons show high-amplitude tim mRNA cycling even in constant darkness conditions (DD) despite minimal expression of other clock genes, suggesting a partial or noncanonical oscillator. In addition, C2 and C3 optic lob

SUBMITTER: Patop IL 

PROVIDER: S-EPMC12776039 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature