Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by profound loss of dopaminergic (DA) neurons, yet the underlying mechanism remains incompletely defined. Mitochondrial toxins can induce acute degeneration of DA neurons and Parkinsonism-like phenotypes in animal models, and epidemiological studies have linked pesticide exposure to increased PD risk; however, the long-term effects of pesticide exposure remain elusive. Here, we examined both the acute and long-term effects of rotenone exposure in mice to understand PD onset, progression, and recovery. A 21-day regimen of rotenone intraperitoneal injections (2.5 mg/kg/day) induced robust Parkinsonism-like deficits by the 4^th week, including impaired locomotion, increased anxiety-like behaviors, and

SUBMITTER: Joshi P 

PROVIDER: S-EPMC12776045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature