Endogenous retrovirus IAP forms virus-like particles and traffics across the maternal-fetal barrier.

ABSTRACT: For 50 years, virus-like particles (VLPs) have been observed in the placentas of many species, but their source and function remain unexplored. Here, we identify intracisternal a-type particle (IAP) elements, specifically the IAPEz-int family, as the likely source of VLPs in the mouse placenta. IAPEz-int instances are expressed throughout placentation and contain intact gag and env sequences critical for the formation of immature and mature particles, respectively. To elucidate a role for IAPEz-int derived VLPs in the mouse placenta, we generated a knock-in mouse containing a full-length element tagged with HA/FLAG. Using this line, we demonstrate that fetal IAPEz-int traffics into and across the maternal decidua. In total, we suggest that placental VLPs derive from IA

SUBMITTER: Bergman AJ 

PROVIDER: S-EPMC12776083 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature