The Algorithm for Reversible Jump Inference of Motifs.

ABSTRACT: Understanding sequence specificity in transcription factor binding is a critical step in understanding gene regulation. DNA-protein binding experiments such as ChIP-chip and ChIP-seq can reveal where on the genome a particular transcription factor of interest is bound, and similar experiments such as ATAC-seq or DNase hypersensitivity can reveal the profile of genome-wide protein binding and chromatin accessibility at the time of an experiment. However, demultiplexing the binding of multiple transcription factors represented in a single occupancy trace can be difficult. While many tools exist for extracting binding motifs from single transcription factor assays, comparatively few exist for deconvolving binding motifs from many transcription factor experiments, and they often require additi

SUBMITTER: Farhat AM 

PROVIDER: S-EPMC12776088 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature