Hippocampal Cdk5 is regulated by distinct stress paradigms in male and female mice.

ABSTRACT: Anxiety and mood disorders have been rising since the COVID-19 pandemic, marked by social isolation and stress. Women are disproportionately affected by stress-related disorders, yet the interaction between social isolation and stress remains understudied in females. Cyclin-dependent kinase 5 (Cdk5) is an atypical kinase that exhibits sex-specific regulation following various stressors but is studied almost exclusively in males. To complement these findings, we examined sex differences in mouse hippocampal Cdk5 mRNA and protein following short and long restraint stress with or without concomitant social isolation stress. While short restraint stress was sufficient to promote anxiety-like in both male and female mice, it did not alter Cdk5. Rather, hippocampal Cdk5 mRNA increased only after

SUBMITTER: Rodriguez-Acevedo KL 

PROVIDER: S-EPMC12776090 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature