Stratifying prognosis in stage III colorectal cancer patients: the role of tumor deposits and lymph node ratio.

ABSTRACT:

Background

The combined effect of tumor deposition (TD) and positive lymph node ratio (LNR) in colorectal cancer (CRC) is unknown. The aim of this study was to investigate the effects of TD and LNR in the prognosis of postoperative CRC patients.

Methods

We retrospectively reviewed 42,701 stage III CRC patients, including 42,470 patients from the Surveillance, Epidemiology, and End Results (SEER) database as a training set, and 231 patients from our hospital as a validation set. We analyzed the relationship of TD and LNR with overall survival (OS) by the Kaplan-Meier method and Cox regression analyses.

Results

Both TD-positive and high LNR (value ≥0.31) were related to worse OS in the training [hazard ratio (HR), 1.518; 95% confidence interval (CI): 1.471-1.565; HR, 1.

SUBMITTER: Wang X 

PROVIDER: S-EPMC12776096 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature